animal tissue nonhuman 88 Animals 79 controlled study 78 priority journal 76 signal transduction 76 article 69 animal experiment 59 mouse 55 animal cell 50 Mice 46 Signal Transduction 44 male 35 animal model 34 protein expression 34 Female 33 female 33 Male 29 animal 25 metabolism 24 unclassified drug 24 rat 20 Humans 19 Article 18 Rats 18 enzyme activity 17 human 17 messenger RNA 17 cell proliferation 15 enzyme activation 14