animal experiment nonhuman 170 controlled study 151 Animals 143 priority journal 135 article 130 animal tissue 101 mouse 93 protein expression 83 Mice 81 animal model 80 Female 74 female 74 male 73 animal cell 72 Male 62 rat 53 Rats 50 unclassified drug 47 animal 45 Humans 42 metabolism 41 down regulation 39 gene expression regulation 39 human 39 Article 38 Gene Expression Regulation 35 cell proliferation 35 gene expression 34 messenger RNA 34