drug effect metabolism article 330 animal 276 Animals 231 nonhuman 197 controlled study 181 priority journal 165 physiology 156 genetics 114 human 111 animal cell 108 rat 107 Rats 103 Humans 101 animal experiment 94 female 92 mouse 86 male 85 unclassified drug 83 Female 82 enzymology 82 Mice 80 Male 79 biosynthesis 73 Article 72 signal transduction 66 animal tissue 63 gene expression regulation 62 in vitro study 61