enzyme active site 46 enzyme activity article 34 priority journal 29 nonhuman 27 controlled study 26 unclassified drug 20 Models, Molecular 15 Catalytic Domain 14 Animals 13 Enzymes 13 Kinetics 13 catalysis 12 Saccharomyces cerevisiae 11 cyclic AMP dependent protein kinase 11 enzyme activation 11 enzyme structure 11 molecular model 11 protein domain 11 Amino Acid Sequence 10 Article 10 Structure-Activity Relationship 10 molecular dynamics 10 Cyclic AMP-Dependent Protein Kinases 9 Enzyme Activation 9 binding affinity 9 human 9 Molecular Sequence Data 8 Proteins 8 Sequence Homology, Amino Acid 8