Article animal tissue nonhuman controlled study 314 Animals 270 animal 262 animal experiment 254 priority journal 202 metabolism 196 male 170 mouse 168 female 148 animal cell 132 animal model 128 physiology 112 Male 100 Mice 100 adult 94 drug effects 90 Female 88 unclassified drug 86 protein expression 84 genetics 72 enzyme activity 58 gene expression 54 human 52 rat 52 in vitro study 50 in vivo study 50 messenger RNA 46