controlled study physiology nonhuman 450 Animals 404 animal 399 metabolism 335 priority journal 313 Article 284 article 266 male 236 female 221 animal experiment 220 Male 202 human 193 Humans 181 Female 171 animal cell 166 animal tissue 166 mouse 152 genetics 140 unclassified drug 133 adult 130 Mice 122 drug effect 115 protein expression 102 signal transduction 86 drug effects 85 human cell 76 cytology 74 rat 74