1 (5 chloro 2 indolylcarbonyl) 4 methylpiperazine 1 1 [2 (amidinothio)ethyl]guanidine 1 2 [(aminoiminomethyl)amino]ethyl carbamimidothioic acid ester dihydrobromide 1 Animals 1 Cell Line, Tumor 1 Cell Proliferation 1 Clozapine 1 Cyclic AMP 1 ERK1/2 1 Extracellular Signal-Regulated MAP Kinases 1 H(4)R 1 H4R 1 Histamine 1 Humans 1 IC 50 1 Male 1 Melanoma 1 Melanoma, Experimental 1 Mice 1 Mice, Nude 1 Neovascularization, Pathologic 1 Phosphorylation 1 Proliferation 1 Receptors, G-Protein-Coupled 1 Receptors, Histamine 1 Signal Transduction 1 Survival 1 Xenograft Model Antitumor Assays 1 animal experiment 1 animal model 1