Use of the domestic chicken to investigate mechanisms of brain maturation
This chapter summarises the relatively recent appreciation of the similarities between the brains of birds and mammals in terms of their neurological and cognitive properties and hence, in many areas of neuroscience, the usefulness of birds as a good model to study human brain function. Brain develo...
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| Autores principales: | , , , , , , |
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| Formato: | CHAP |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_97816087_v_n_p29_Atkinson |
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| Sumario: | This chapter summarises the relatively recent appreciation of the similarities between the brains of birds and mammals in terms of their neurological and cognitive properties and hence, in many areas of neuroscience, the usefulness of birds as a good model to study human brain function. Brain development in humans involves a protracted and highly coordinated set of maturation changes that take place over more than a decade to fine tune the neural circuitry established in infancy. The domestic chicken is particularly suitable to study the neurobiological processes involved in brain maturation because in chickens, as in humans, these changes are protracted and occur in a distinct phase of development temporally separated from the synapse formation events that established the neural circuits. We review the molecular, cellular and behavioural investigations of the mechanisms involved in brain maturation in chicken forebrain. We review some non-invasive electrophysiological techniques for assessing the functional maturation of chicken brain and present one new technique. We also present new mathematical methods for analysing such non-invasive electrophysiological data during normal or abnormal brain development. © 2010 Nova Science Publishers, Inc. All rights reserved. |
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