Experimental protoporphyria: Effect of bile acids on liver damage induced by griseofulvin

The effect of bile acids administration to an experimental mice model of Protoporphyria produced by griseofulvin (Gris) was investigated. The aim was to assess whether porphyrin excretion could be accelerated by bile acids treatment in an attempt to diminish liver damage induced by Gris. Liver damag...

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Detalles Bibliográficos
Autores principales:	Martinez, M.D.C., Ruspini, S.F., Afonso, S.G., Meiss, R., Buzaleh, A.M., Batlle, A.
Formato:	JOUR
Materias:	alkaline phosphatase biological marker chenodeoxycholic acid cytochrome P450 dehydrocholic acid deoxycholic acid gamma glutamyltransferase glutathione glutathione reductase glutathione transferase griseofulvin heme porphyrin protoporphyrin superoxide dismutase ursodeoxycholic acid catalase glutathione peroxidase animal experiment animal model animal tissue Article biliary excretion controlled study drug effect drug efficacy enzyme activity erythropoietic protoporphyria immunohistochemistry lipid peroxidation liver histology liver injury male mouse nonhuman oxidative stress animal Chemical and Drug Induced Liver Injury chemically induced drug effects human metabolism pathology Protoporphyria, Erythropoietic Mus Animals Catalase Chenodeoxycholic Acid Dehydrocholic Acid Deoxycholic Acid Glutathione Peroxidase Glutathione Reductase Glutathione Transferase Griseofulvin Humans Lipid Peroxidation Mice Oxidative Stress Porphyrins Superoxide Dismutase Ursodeoxycholic Acid
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_23146133_v2015_n_p_Martinez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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