The thyroid hormone triiodothyronine reinvigorates dendritic cells and potentiates anti-tumor immunity

Dendritic cell (DC) cancer vaccines have shown limited clinical benefit. Thus, the identification of signals and molecular pathways that potentiate the immunogenicity of DCs has become a major challenge in cancer research. Our studies demonstrate that triiodothyronine endows DCs with enhanced abilit...

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Detalles Bibliográficos
Autores principales: Alamino, V.A., Montesinos, M.M., Rabinovich, G.A., Pellizas, C.G.
Formato: JOUR
Materias:
Cancer vaccination
Dendritic cell
Immunotherapy
Thyroid hormone
Triiodothyronine
cancer vaccine
gamma interferon
liothyronine
Article
cell differentiation
cross presentation
dendritic cell
immune response
immunogenicity
nonhuman
protein expression
signal transduction
tumor growth
tumor immunity
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_21624011_v5_n1_p_Alamino
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Dendritic cell (DC) cancer vaccines have shown limited clinical benefit. Thus, the identification of signals and molecular pathways that potentiate the immunogenicity of DCs has become a major challenge in cancer research. Our studies demonstrate that triiodothyronine endows DCs with enhanced ability to stimulate cytotoxic T-cell responses with implications in DC-based immunotherapy. © 2016 Taylor & Francis Group, LLC.

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