Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis

Similar molecular machinery is activated in neurons following an electrical stimulus that induces synaptic changes and after learning sessions that trigger memory formation. Then, to achieve perdurability of these processes protein synthesis is required for the reinforcement of the changes induced i...

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Detalles Bibliográficos
Autores principales:	Moncada, D., Ballarini, F., Viola, H.
Formato:	JOUR
Materias:	behavioral tagging hippocampus human hypothesis learning long term depression long term memory long term potentiation memory memory consolidation nerve cell plasticity nonhuman protein synthesis Review spatial memory state dependent learning synaptic transmission animal animal behavior behavior physiology synapse Animals Behavior Behavior, Animal Humans Memory Neuronal Plasticity Synapses
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_20905904_v2015_n_p_Moncada
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_20905904_v2015_n_p_Moncada
record_format	dspace
spelling	todo:paper_20905904_v2015_n_p_Moncada2023-10-03T16:39:20Z Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis Moncada, D. Ballarini, F. Viola, H. behavioral tagging hippocampus human hypothesis learning long term depression long term memory long term potentiation memory memory consolidation nerve cell plasticity nonhuman protein synthesis Review spatial memory state dependent learning synaptic transmission animal animal behavior behavior memory physiology synapse Animals Behavior Behavior, Animal Humans Memory Neuronal Plasticity Synapses Similar molecular machinery is activated in neurons following an electrical stimulus that induces synaptic changes and after learning sessions that trigger memory formation. Then, to achieve perdurability of these processes protein synthesis is required for the reinforcement of the changes induced in the network. The synaptic tagging and capture theory provided a strong framework to explain synaptic specificity and persistence of electrophysiological induced plastic changes. Ten years later, the behavioral tagging hypothesis (BT) made use of the same argument, applying it to learning and memory models. The hypothesis postulates that the formation of lasting memories relies on at least two processes: the setting of a learning tag and the synthesis of plasticity related proteins, which once captured at tagged sites allow memory consolidation. BT explains how weak events, only capable of inducing transient forms of memories, can result in lasting memories when occurring close in time with other behaviorally relevant experiences that provide proteins. In this review, we detail the findings supporting the existence of BT process in rodents, leading to the consolidation, persistence, and interference of a memory. We focus on the molecular machinery taking place in these processes and describe the experimental data supporting the BT in humans. © 2015 Diego Moncada et al. Fil:Moncada, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_20905904_v2015_n_p_Moncada
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	behavioral tagging hippocampus human hypothesis learning long term depression long term memory long term potentiation memory memory consolidation nerve cell plasticity nonhuman protein synthesis Review spatial memory state dependent learning synaptic transmission animal animal behavior behavior memory physiology synapse Animals Behavior Behavior, Animal Humans Memory Neuronal Plasticity Synapses
spellingShingle	behavioral tagging hippocampus human hypothesis learning long term depression long term memory long term potentiation memory memory consolidation nerve cell plasticity nonhuman protein synthesis Review spatial memory state dependent learning synaptic transmission animal animal behavior behavior memory physiology synapse Animals Behavior Behavior, Animal Humans Memory Neuronal Plasticity Synapses Moncada, D. Ballarini, F. Viola, H. Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis
topic_facet	behavioral tagging hippocampus human hypothesis learning long term depression long term memory long term potentiation memory memory consolidation nerve cell plasticity nonhuman protein synthesis Review spatial memory state dependent learning synaptic transmission animal animal behavior behavior memory physiology synapse Animals Behavior Behavior, Animal Humans Memory Neuronal Plasticity Synapses
description	Similar molecular machinery is activated in neurons following an electrical stimulus that induces synaptic changes and after learning sessions that trigger memory formation. Then, to achieve perdurability of these processes protein synthesis is required for the reinforcement of the changes induced in the network. The synaptic tagging and capture theory provided a strong framework to explain synaptic specificity and persistence of electrophysiological induced plastic changes. Ten years later, the behavioral tagging hypothesis (BT) made use of the same argument, applying it to learning and memory models. The hypothesis postulates that the formation of lasting memories relies on at least two processes: the setting of a learning tag and the synthesis of plasticity related proteins, which once captured at tagged sites allow memory consolidation. BT explains how weak events, only capable of inducing transient forms of memories, can result in lasting memories when occurring close in time with other behaviorally relevant experiences that provide proteins. In this review, we detail the findings supporting the existence of BT process in rodents, leading to the consolidation, persistence, and interference of a memory. We focus on the molecular machinery taking place in these processes and describe the experimental data supporting the BT in humans. © 2015 Diego Moncada et al.
format	JOUR
author	Moncada, D. Ballarini, F. Viola, H.
author_facet	Moncada, D. Ballarini, F. Viola, H.
author_sort	Moncada, D.
title	Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis
title_short	Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis
title_full	Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis
title_fullStr	Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis
title_full_unstemmed	Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis
title_sort	behavioral tagging: a translation of the synaptic tagging and capture hypothesis
url	http://hdl.handle.net/20.500.12110/paper_20905904_v2015_n_p_Moncada
work_keys_str_mv	AT moncadad behavioraltaggingatranslationofthesynaptictaggingandcapturehypothesis AT ballarinif behavioraltaggingatranslationofthesynaptictaggingandcapturehypothesis AT violah behavioraltaggingatranslationofthesynaptictaggingandcapturehypothesis
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Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis

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