Regulation of signaling directionality revealed by 3D snapshots of a kinase: Regulator complex in action

Two-component systems (TCS) are protein machineries that enable cells to respond to input signals. Histidine kinases (HK) are the sensory component, transferring information toward downstream response regulators (RR). HKs transfer phosphoryl groups to their specific RRs, but also dephosphorylate the...

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Detalles Bibliográficos
Autores principales: Trajtenberg, F., Imelio, J.A., Machado, M.R., Larrieux, N., Marti, M.A., Obal, G., Mechaly, A.E., Buschiazzo, A.
Formato: JOUR
Materias:
phosphatase
phosphotransferase
protein histidine kinase
transcription factor
amino acid sequence
Article
Bacillus subtilis
cloning
computer model
crystal structure
crystallization
entropy
isothermal titration calorimetry
molecular dynamics
mutagenesis
phosphate transport
point mutation
protein conformation
protein dephosphorylation
protein expression
protein purification
signal transduction
size exclusion chromatography
structure analysis
three dimensional imaging
X ray crystallography
X ray diffraction
chemistry
enzymology
metabolism
molecular model
phosphorylation
protein processing
Crystallography, X-Ray
Histidine Kinase
Models, Molecular
Phosphorylation
Protein Conformation
Protein Processing, Post-Translational
Signal Transduction
Transcription Factors
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_2050084X_v5_nDECEMBER2016_p_Trajtenberg
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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