N-glycosylation Triggers a Dual Selection Pressure in Eukaryotic Secretory Proteins

Nearly one third of the eukaryotic proteome traverses the secretory pathway and most of these proteins are N-glycosylated in the lumen of the endoplasmic reticulum. N-glycans fulfill multiple structural and biological functions, and are crucial for productive folding of many glycoproteins. N-glycosy...

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Detalles Bibliográficos
Autores principales: Medus, M.L., Gomez, G.E., Zacchi, L.F., Couto, P.M., Labriola, C.A., Labanda, M.S., Bielsa, R.C., Clérico, E.M., Schulz, B.L., Caramelo, J.J.
Formato: JOUR
Materias:
glycoprotein
membrane protein
protein binding
animal
biology
chemistry
Chlorocebus aethiops
CV-1 cell line
endoplasmic reticulum
eukaryotic cell
genetic disorder
genetic selection
genetics
glycosylation
human
metabolism
molecular model
procedures
protein conformation
Animals
Cercopithecus aethiops
Computational Biology
COS Cells
Endoplasmic Reticulum
Eukaryotic Cells
Genetic Diseases, Inborn
Glycoproteins
Glycosylation
Humans
Membrane Proteins
Models, Molecular
Protein Binding
Protein Conformation
Selection, Genetic
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_20452322_v7_n1_p_Medus
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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