Arsenic trioxide alters the differentiation of mouse embryonic stem cell into cardiomyocytes

Chronic arsenic exposure is associated with increased morbidity and mortality for cardiovascular diseases. Arsenic increases myocardial infarction mortality in young adulthood, suggesting that exposure during foetal life correlates with cardiac alterations emerging later. Here, we investigated the m...

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Detalles Bibliográficos
Autores principales: Rebuzzini, P., Cebral, E., Fassina, L., Alberto Redi, C., Zuccotti, M., Garagna, S.
Formato: JOUR
Materias:
actinin
antineoplastic agent
arsenic trioxide
Brachyury protein
connexin 43
fetoprotein
homeobox protein Nkx-2.5
homeodomain protein
Nkx2-5 protein, mouse
organoarsenic derivative
oxide
T box transcription factor
transcription factor
transcription factor GATA 4
troponin C
troponin T
animal
biomechanics
cardiac muscle cell
cell differentiation
cell line
drug effects
fluorescent antibody technique
gene expression
genetics
metabolism
mouse
mouse embryonic stem cell
multicellular spheroid
reverse transcription polymerase chain reaction
sarcomere
time factor
Western blotting
Actinin
Animals
Antineoplastic Agents
Arsenicals
Biomechanical Phenomena
Blotting, Western
Cell Differentiation
Cell Line
Connexin 43
Fetal Proteins
Fluorescent Antibody Technique
GATA4 Transcription Factor
Gene Expression
Homeobox Protein Nkx-2.5
Homeodomain Proteins
Mice
Mouse Embryonic Stem Cells
Myocytes, Cardiac
Oxides
Reverse Transcriptase Polymerase Chain Reaction
Sarcomeres
Spheroids, Cellular
T-Box Domain Proteins
Time Factors
Transcription Factors
Troponin C
Troponin T
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_20452322_v5_n_p_Rebuzzini
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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