High RAC3 expression levels are required for induction and maintaining of cancer cell stemness

RAC3 is a transcription coactivator, usually overexpressed in several tumors and required to maintain the pluripotency in normal stem cells. In this work we studied the association between RAC3 overexpression on cancer cell stemness and the capacity of this protein to induce cancer stem properties i...

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Detalles Bibliográficos
Autores principales:	Panelo, L.C., Machado, M.S., Rubio, M.F., Jaworski, F., Alvarado, C.V., Paz, L.A., Urtreger, A.J., Vazquez, E., Costas, M.A.
Formato:	JOUR
Materias:	Cancer stem cell Mesenchymal cells RAC3 Stem cells Tumor CD133 antigen octamer transcription factor 4 protein RAC3 transcription factor transcription factor NANOG unclassified drug advanced cancer animal experiment animal model animal tissue Article cancer staging cancer stem cell clonogenesis colorectal tumor controlled study embryo epithelial mesenchymal transition gene silencing HCT 116 cell line HEK293 cell line human human cell in vitro study in vivo study male malignant transformation mesenchyme cell microarray analysis mouse nonhuman protein expression
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_19492553_v9_n5_p5848_Panelo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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