Improving risk stratification of patients with childhood acute lymphoblastic leukemia: Glutathione-S-Transferases polymorphisms are associated with increased risk of relapse

The inclusion of genotype at Acute Lymphoblastic Leukemia (ALL) diagnosis as a genetic predictor of disease outcome is under constant study. However, results are inconclusive and seem to be population specific. We analyzed the predictive value of germline polymorphisms for childhood ALL relapse and...

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Autores principales: Leonardi, D.B., Abbate, M., Riccheri, M.C., Nuñez, M., Alfonso, G., Gueron, G., De Siervi, A., Vazquez, E., Cotignola, J.
Formato: JOUR
Materias:
Acute leukemia
Glutathione-S-Transferase
Polymorphism
Predictor
Relapse
glutathione transferase
glutathione transferase M1
glutathione transferase P1
glutathione transferase T1
multidrug resistance protein 1
acute lymphoblastic leukemia
adolescent
adult
Article
cancer prognosis
cancer risk
cancer survival
child
childhood leukemia
controlled study
female
gene
gene frequency
genetic association
genetic risk
genetic variability
genotype
GSTM1 gene
GSTP1 gene
GSTT1 gene
high risk population
human
infant
leukemia relapse
major clinical study
male
MDR1 gene
MTHFR gene
multiplex polymerase chain reaction
newborn
predictive value
recurrence free survival
retrospective study
risk assessment
single nucleotide polymorphism
survival analysis
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19492553_v8_n1_p110_Leonardi
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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