Prostate cancer cell-stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases

Bone is the most common site of prostate cancer (PCa) progression to a therapy-resistant, lethal phenotype. We found that blockade of fibroblast growth factor receptors (FGFRs) with the receptor tyrosine kinase inhibitor dovitinib has clinical activity in a subset of men with castration-resistant PC...

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Autores principales:	Wan, X., Corn, P.G., Yang, J., Palanisamy, N., Starbuck, M.W., Efstathiou, E., Li-Ning Tapia, E.M., Zurita, A.J., Aparicio, A., Ravoori, M.K., Vazquez, E.S., Robinson, D.R., Wu, Y.-M., Cao, X., Iyer, M.K., McKeehan, W., Kundra, V., Wang, F., Troncoso, P., Chinnaiyan, A.M., Logothetis, C.J., Navone, N.M.
Formato:	JOUR
Materias:	dovitinib fibroblast growth factor fibroblast growth factor receptor 1 prostate specific antigen 4-amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one antineoplastic agent benzimidazole derivative fibroblast growth factor 2 quinolone derivative animal experiment animal model antiangiogenic activity antineoplastic activity Article bone metastasis bone quality bone scintiscanning cancer cell castration resistant prostate cancer cell interaction controlled study drug megadose drug targeting human human cell low drug dose lymph node lymph node size molecular interaction mouse musculoskeletal system parameters nonhuman osteoblast positive feedback prostate cancer protein blood level protein expression receptor blocking signal transduction stroma cell tumor microenvironment tumor volume animal apoptosis bone Bone Neoplasms disease model drug effects drug screening gene expression regulation genetics male metabolism Neovascularization, Pathologic pathology Prostatic Neoplasms secondary tumor cell line vascularization Animals Antineoplastic Agents Apoptosis Benzimidazoles Bone and Bones Cell Line, Tumor Disease Models, Animal Fibroblast Growth Factor 2 Gene Expression Regulation, Neoplastic Humans Male Mice Osteoblasts Prostatic Neoplasms, Castration-Resistant Quinolones Receptor, Fibroblast Growth Factor, Type 1 Signal Transduction Stromal Cells Tumor Microenvironment Xenograft Model Antitumor Assays
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_19466234_v6_n252_p_Wan
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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