Retroviral-like features in the monomer of the major satellite DNA from the south american rodents of the genus ctenomys

It is well known that uninfected mammalian cells contain DNA sequences which are closely related to retroviral genomic segments. However, these sequences seldom (if ever) have been found associated to highly repetitive (satellite) DNA. RPCS is a 348 bp monomer of a major satellite DNA from the South...

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Detalles Bibliográficos
Autores principales: Rossi, M.S., Pesce, C.G., Reig, O.A., Kornblihtt, A.R., Zorzópulos, J.
Formato: JOUR
Materias:
Caviomorph rodents
Retroviral LTRs
Satellite DNA
CCAAT enhancer binding protein
CCAAT Enhancer Binding Proteins
DNA binding protein
DNA Binding Proteins
nuclear protein
satellite DNA
transcription factor
transcription factor nuclear factor 1
animal
article
binding site
genetics
metabolism
molecular genetics
nucleotide sequence
Retrovirus
rodent
TATA box
Animal
Base Sequence
Binding Sites
CCAAT-Enhancer-Binding Proteins
DNA, Satellite
DNA-Binding Proteins
Molecular Sequence Data
Nuclear Proteins
Retroviridae
Rodentia
TATA Box
Transcription Factors
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19401744_v3_n6_p379_Rossi
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:It is well known that uninfected mammalian cells contain DNA sequences which are closely related to retroviral genomic segments. However, these sequences seldom (if ever) have been found associated to highly repetitive (satellite) DNA. RPCS is a 348 bp monomer of a major satellite DNA from the South American rodents of the genus Ctenomys. It was found that RPCS contains several elements which are typical of the V) region of retroviral LTRs. These elements are: a) a polypurine tract; b) two enhancer core sequences; c) two NF1 binding sites; d) two C/EBP binding sites; e) two CCAAT-motifs; f) a TATA box, and g) two putative polyadenylation motifs. Furthermore, the relative positions of these elements are as in the U, retroviral regions. © 1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

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