Deregulation of mitochondria-shaping proteins Opa-1 and Drp-1 in manganese-induced apoptosis

Mitochondria are dynamic organelles that undergo fusion and fission processes. These events are regulated by mitochondria-shaping proteins. Changes in the expression and/or localization of these proteins lead to a mitochondrial dynamics impairment and may promote apoptosis. Increasing evidence corre...

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Detalles Bibliográficos
Autores principales:	Alaimo, A., Gorojod, R.M., Beauquis, J., Muñoz, M.J., Saravia, F., Kotler, M.L.
Formato:	JOUR
Materias:	manganese mitochondrial protein protein Drp 1 protein Opa 1 small interfering RNA unclassified drug animal cell animal experiment animal model animal tissue apoptosis article astrocyte basal ganglion bioaccumulation brain region cell disruption cellular distribution controlled study cytosol cytotoxicity disorders of mitochondrial functions male molecular dynamics nonhuman parkinsonism protein analysis protein expression protein function protein localization protein transport rat toxicity testing upregulation Animals Apoptosis Cell Line, Tumor Cyclosporine Dynamins Gene Expression Regulation GTP Phosphohydrolases Intracellular Space Male Manganese Membrane Potential, Mitochondrial Mitochondria Neostriatum Protein Transport Rats Rats, Sprague-Dawley
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_19326203_v9_n3_p_Alaimo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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