Effects of dimethyl sulfoxide in cholesterol-containing lipid membranes: A comparative study of experiments in silico and with cells

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Dimethyl sulfoxide (DMSO) has been known to enhance cell membrane permeability of drugs or DNA. Molecular dynamics (MD) simulations with single-component lipid bilayers predicted the existence of three regimes of action of DMSO: membrane loosening, pore formation and bilayer collapse. We show here t...

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Detalles Bibliográficos
Autores principales: de Ménorval, M.-A., Mir, L.M., Fernández, M.L., Reigada, R.
Formato: JOUR
Materias:
calcium ion
dimethyl sulfoxide
iodide
water
animal cell
article
calcium cell level
cell assay
cell membrane permeability
comparative study
computer model
concentration (parameters)
controlled study
fibroblast
lipid bilayer
lipid membrane
molecular dynamics
molecular interaction
nonhuman
prediction
structure analysis
Animals
Cell Line
Cell Membrane
Cell Membrane Permeability
Cholesterol
Computational Biology
Cricetinae
Dimethyl Sulfoxide
Dose-Response Relationship, Drug
Lipid Bilayers
Molecular Conformation
Molecular Dynamics Simulation
Porosity
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19326203_v7_n7_p_deMenorval
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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