Mode of action of the sesquiterpene lactones psilostachyin and psilostachyin C on trypanosoma cruzi

Trypanosoma cruzi is the causative agent of Chagas' disease, which is a major endemic disease in Latin America and is recognized by the WHO as one of the 17 neglected tropical diseases in the world. Psilostachyin and psilostachyin C, two sesquiterpene lactones isolated from Ambrosia spp., have...

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Detalles Bibliográficos
Autores principales: Sülsen, V.P., Puente, V., Papademetrio, D., Batlle, A., Martino, V.S., Frank, F.M., Lombardo, M.E.
Formato: JOUR
Materias:
cruzipain
hemin
lipocortin 5
phosphatidylserine
propidium iodide
psilostachyin
psilostachyin C
reactive oxygen metabolite
sesquiterpene lactone derivative
squalene
sterol
trypanothione reductase
unclassified drug
fused heterocyclic rings
lactone
plant extract
psilostachyin A
pyrone derivative
sesquiterpene
Ambrosia scabra
Ambrosia tenuifolia
apoptosis
Article
bacterium isolation
biosynthesis
cell death
controlled study
drug activity
drug isolation
drug protein binding
mitochondrial membrane potential
nonhuman
oxidative stress
ragweed
structure analysis
Trypanosoma cruzi
TUNEL assay
Chagas disease
chemistry
drug effects
human
metabolism
parasitology
pathogenicity
Ambrosia
Apoptosis
Chagas Disease
Hemin
Heterocyclic Compounds, 3-Ring
Humans
Lactones
Plant Extracts
Pyrones
Reactive Oxygen Species
Sesquiterpenes
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19326203_v11_n3_p_Sulsen
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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