Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity
Background: It has been shown in experimental and theoretical work that covalently modified signaling cascades naturally exhibit bidirectional signal propagation via a phenomenon known as retroactivity. An important consequence of retroactivity, which arises due to enzyme sequestration in covalently...
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| Autores principales: | Wynn, M.L., Ventura, A.C., Sepulchre, J.A., García, H.J., Merajver, S.D. |
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| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_17520509_v5_n_p_Wynn |
| Aporte de: |
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