Structural analysis of the N-glycans of the major cysteine proteinase of Trypanosoma cruzi: Identification of sulfated high-mannose type oligosaccharides

Trypanosoma cruzi, the parasitic protozoan that causes Chagas disease, contains a major cysteine proteinase, cruzipain. This lysosomal enzyme bears an unusual C-terminal extension that contains a number of post-translational modifications, and most antibodies in natural and experimental infections a...

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Detalles Bibliográficos
Autores principales: Barboza, M., Duschak, V.G., Fukuyama, Y., Nonami, H., Erra-Balsells, R., Cazzulo, J.J., Couto, A.S.
Formato: JOUR
Materias:
Cruzipain
Nor-harmane
Sulfated oligosaccharides
Trypanosoma cruzi
UV-MALDI-TOF MS
cruzipain
cysteine proteinase
deoxysugar
glycan
glycosidase
mannose
oligosaccharide
anion exchange chromatography
article
carboxy terminal sequence
deglycosylation
fucosylation
matrix assisted laser desorption ionization time of flight mass spectrometry
nonhuman
priority journal
protein analysis
sialylation
structure analysis
sulfation
Animals
Cysteine Endopeptidases
Electrophoresis, Polyacrylamide Gel
Fucose
Mannose
Oligosaccharides, Branched-Chain
Silver Staining
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Time Factors
Protozoa
Trypanosomatidae
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_1742464X_v272_n15_p3803_Barboza
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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