Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis

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Olfactory epithelium has the capability to continuously regenerate olfactory receptor neurons throughout life. Adult neurogenesis results from proliferation and differentiation of neural stem cells, and consequently, olfactory neuroepithelium offers an excellent opportunity to study neural regenerat...

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Autores principales: Frontera, J.L., Cervino, A.S., Jungblut, L.D., Paz, D.A.
Formato: JOUR
Materias:
Neural stem cells
Neurogenesis
Neurotrophins
Olfactory bulb
Olfactory neurons
Sustentacular cells
brain derived neurotrophic factor
animal
metabolism
nerve regeneration
nervous system development
olfactory bulb
olfactory epithelium
pathology
pathophysiology
physiology
Xenopus laevis
Animals
Brain-Derived Neurotrophic Factor
Nerve Regeneration
Olfactory Bulb
Olfactory Mucosa
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_16180402_v198_n_p41_Frontera
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_16180402_v198_n_p41_Frontera2023-10-03T16:28:28Z Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis Frontera, J.L. Cervino, A.S. Jungblut, L.D. Paz, D.A. Neural stem cells Neurogenesis Neurotrophins Olfactory bulb Olfactory neurons Sustentacular cells brain derived neurotrophic factor animal metabolism nerve regeneration nervous system development olfactory bulb olfactory epithelium pathology pathophysiology physiology Xenopus laevis Animals Brain-Derived Neurotrophic Factor Nerve Regeneration Neurogenesis Olfactory Bulb Olfactory Mucosa Xenopus laevis Olfactory epithelium has the capability to continuously regenerate olfactory receptor neurons throughout life. Adult neurogenesis results from proliferation and differentiation of neural stem cells, and consequently, olfactory neuroepithelium offers an excellent opportunity to study neural regeneration and the factors involved in the maintenance and regeneration of all their cell types. We analyzed the expression of BDNF in the olfactory system under normal physiological conditions as well as during a massive regeneration induced by chemical destruction of the olfactory epithelium in Xenopus laevis larvae. We described the expression and presence of BDNF in the olfactory epithelium and bulb. In normal physiological conditions, sustentacular (glial) cells and a few scattered basal (stem) cells express BDNF in the olfactory epithelium as well as the granular cells in the olfactory bulb. Moreover, during massive regeneration, we demonstrated a drastic increase in basal cells expressing BDNF as well as an increase in BDNF in the olfactory bulb and nerve. Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system. Copyright © 2014 Elsevier GmbH. All rights reserved. Fil:Jungblut, L.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Paz, D.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_16180402_v198_n_p41_Frontera
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Neural stem cells
Neurogenesis
Neurotrophins
Olfactory bulb
Olfactory neurons
Sustentacular cells
brain derived neurotrophic factor
animal
metabolism
nerve regeneration
nervous system development
olfactory bulb
olfactory epithelium
pathology
pathophysiology
physiology
Xenopus laevis
Animals
Brain-Derived Neurotrophic Factor
Nerve Regeneration
Neurogenesis
Olfactory Bulb
Olfactory Mucosa
Xenopus laevis
spellingShingle Neural stem cells
Neurogenesis
Neurotrophins
Olfactory bulb
Olfactory neurons
Sustentacular cells
brain derived neurotrophic factor
animal
metabolism
nerve regeneration
nervous system development
olfactory bulb
olfactory epithelium
pathology
pathophysiology
physiology
Xenopus laevis
Animals
Brain-Derived Neurotrophic Factor
Nerve Regeneration
Neurogenesis
Olfactory Bulb
Olfactory Mucosa
Xenopus laevis
Frontera, J.L.
Cervino, A.S.
Jungblut, L.D.
Paz, D.A.
Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis
topic_facet Neural stem cells
Neurogenesis
Neurotrophins
Olfactory bulb
Olfactory neurons
Sustentacular cells
brain derived neurotrophic factor
animal
metabolism
nerve regeneration
nervous system development
olfactory bulb
olfactory epithelium
pathology
pathophysiology
physiology
Xenopus laevis
Animals
Brain-Derived Neurotrophic Factor
Nerve Regeneration
Neurogenesis
Olfactory Bulb
Olfactory Mucosa
Xenopus laevis
description Olfactory epithelium has the capability to continuously regenerate olfactory receptor neurons throughout life. Adult neurogenesis results from proliferation and differentiation of neural stem cells, and consequently, olfactory neuroepithelium offers an excellent opportunity to study neural regeneration and the factors involved in the maintenance and regeneration of all their cell types. We analyzed the expression of BDNF in the olfactory system under normal physiological conditions as well as during a massive regeneration induced by chemical destruction of the olfactory epithelium in Xenopus laevis larvae. We described the expression and presence of BDNF in the olfactory epithelium and bulb. In normal physiological conditions, sustentacular (glial) cells and a few scattered basal (stem) cells express BDNF in the olfactory epithelium as well as the granular cells in the olfactory bulb. Moreover, during massive regeneration, we demonstrated a drastic increase in basal cells expressing BDNF as well as an increase in BDNF in the olfactory bulb and nerve. Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system. Copyright © 2014 Elsevier GmbH. All rights reserved.
format JOUR
author Frontera, J.L.
Cervino, A.S.
Jungblut, L.D.
Paz, D.A.
author_facet Frontera, J.L.
Cervino, A.S.
Jungblut, L.D.
Paz, D.A.
author_sort Frontera, J.L.
title Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis
title_short Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis
title_full Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis
title_fullStr Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis
title_full_unstemmed Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis
title_sort brain-derived neurotrophic factor (bdnf) expression in normal and regenerating olfactory epithelium of xenopus laevis
url http://hdl.handle.net/20.500.12110/paper_16180402_v198_n_p41_Frontera
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AT pazda brainderivedneurotrophicfactorbdnfexpressioninnormalandregeneratingolfactoryepitheliumofxenopuslaevis
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