Pharmacophore model for antiepileptic drugs acting on sodium channels

Fifteen antiepileptic drugs (AED), active against the maximal electroshock seizure test and able to block the neuronal voltage-dependent sodium channel, have been studied by means of a similarity analysis. Structural and electronic, quantum chemically derived characteristics are compared. Rigid anal...

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Detalles Bibliográficos
Autores principales: Tasso, S.M., Bruno-Blanch, L.E., Estiú, G.L.
Formato: JOUR
Materias:
Antiepileptic
Pharmacophore
Quantum chemical molecular design
Rational drug design
Sodium channel
anticonvulsive agent
carbamazepine
dezinamide
ethosuximide
felbamate
gabapentin
lamotrigine
oxcarbazepine
phenytoin
ralitoline
remacemide
rufinamide
sodium channel
sodium channel blocking agent
topiramate
valproic acid
vinpocetine
zonisamide
anticonvulsant activity
article
chemical interaction
computer model
conformation
controlled study
drug mechanism
drug potency
drug structure
electric shock
nerve block
pharmacophore
priority journal
quantitative structure activity relation
quantum chemistry
seizure
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_16102940_v7_n7_p231_Tasso
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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