Sialic Acid Glycobiology Unveils Trypanosoma cruzi Trypomastigote Membrane Physiology

Trypanosoma cruzi, the flagellate protozoan agent of Chagas disease or American trypanosomiasis, is unable to synthesize sialic acids de novo. Mucins and trans-sialidase (TS) are substrate and enzyme, respectively, of the glycobiological system that scavenges sialic acid from the host in a crucial i...

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Detalles Bibliográficos
Autores principales: Lantos, A.B., Carlevaro, G., Araoz, B., Ruiz Diaz, P., Camara, M.D.L.M., Buscaglia, C.A., Bossi, M., Yu, H., Chen, X., Bertozzi, C.R., Mucci, J., Campetella, O.
Formato: JOUR
Materias:
glycosylphosphatidylinositol anchored protein
mucin
phosphatidylinositol diacylglycerol lyase
sialic acid
sialidase
glycoprotein
n acetylneuraminic acid
trans-sialidase
affinity chromatography
Article
atomic force microscopy
cell migration
cell proliferation
Chagas disease
controlled study
enzyme activity
glycobiology
immunofluorescence microscopy
mass spectrometry
membrane fluidity
membrane microparticle
nonhuman
parasite survival
parasite virulence
protein expression
protein purification
sialylation
transmission electron microscopy
Trypanosoma cruzi
trypomastigote
ultracentrifugation
Western blotting
animal
Bagg albino mouse
disease model
fluorescence microscopy
host parasite interaction
image processing
metabolism
microscopy
mouse
parasitology
pathogenicity
physiology
procedures
virulence
Animals
Cell-Derived Microparticles
Chagas Disease
Disease Models, Animal
Glycoproteins
Host-Parasite Interactions
Image Processing, Computer-Assisted
Mass Spectrometry
Mice
Mice, Inbred BALB C
Microscopy
Microscopy, Fluorescence
Mucins
N-Acetylneuraminic Acid
Neuraminidase
Virulence
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_15537366_v12_n4_p_Lantos
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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