Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity

Obesity is associated with physical inactivity, which exacerbates the health consequences of weight gain. However, the mechanisms that mediate this association are unknown. We hypothesized that deficits in dopamine signaling contribute to physical inactivity in obesity. To investigate this, we quant...

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Detalles Bibliográficos
Autores principales: Friend, D.M., Devarakonda, K., O'Neal, T.J., Skirzewski, M., Papazoglou, I., Kaplan, A.R., Liow, J.-S., Guo, J., Rane, S.G., Rubinstein, M., Alvarez, V.A., Hall, K.D., Kravitz, A.V.
Formato: JOUR
Materias:
D2
dopamine
exercise
obese
obesity
physical activity
striatum
weight loss
dopamine 2 receptor
protein binding
animal experiment
animal model
Article
basal ganglion
controlled study
corpus striatum
diet induced obesity
mouse
nerve cell
nonhuman
physical inactivity
priority journal
signal transduction
weight gain
action potential
adverse effects
animal
C57BL mouse
lipid diet
male
metabolism
mouse mutant
movement (physiology)
pathophysiology
physiology
Action Potentials
Animals
Basal Ganglia
Corpus Striatum
Diet, High-Fat
Male
Mice, Inbred C57BL
Mice, Obese
Movement
Neurons
Obesity
Physical Conditioning, Animal
Protein Binding
Receptors, Dopamine D2
Weight Gain
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_15504131_v25_n2_p312_Friend
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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