Thermal Stability of Globins: Implications of Flexibility and Heme Coordination Studied by Molecular Dynamics Simulations

Proteins are sensitive to temperature, and abrupt changes in the normal temperature conditions can have a profound impact on both structure and function, leading to protein unfolding. However, the adaptation of certain organisms to extreme conditions raises questions about the structural features th...

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Detalles Bibliográficos
Autores principales: Julió Plana, L., Nadra, A.D., Estrin, D.A., Luque, F.J., Capece, L.
Formato: JOUR
Materias:
Hemoglobin
Molecular dynamics
Porphyrins
Stability
Thermodynamic stability
Classical molecular dynamics
Horse heart myoglobin
Inherent flexibility
Molecular dynamics simulations
Protein thermostabilities
Structural fluctuations
Temperature conditions
Thermal fluctuations
Proteins
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_15499596_v59_n1_p441_JulioPlana
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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