E2F1 and E2F2 induction in response to DNA damage preserves genomic stability in neuronal cells

E2F transcription factors regulate a wide range of biological processes, including the cellular response to DNA damage. In the present study, we examined whether E2F family members are transcriptionally induced following treatment with several genotoxic agents, and have a role on the cell DNA damage...

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Detalles Bibliográficos
Autores principales:	Castillo, D.S., Campalans, A., Belluscio, L.M., Carcagno, A.L., Radicell, J.P., Cánepa, E.T., Pregi, N.
Formato:	JOUR
Materias:	DNA damage response DNA repair E2F transcription factor Genomic stability Neuronal cells ATM protein ATR protein caspase 3 cycloheximide histone acetyltransferase GCN5 histone H2AX messenger RNA mitogen activated protein kinase kinase Rad51 protein transcription factor E2F1 transcription factor E2F2 zinostatin dactinomycin H2AFX protein, human histone histone acetyltransferase PCAF hydrogen peroxide mitogen activated protein kinase kinase kinase p300-CBP-associated factor protein synthesis inhibitor animal cell apoptosis Article cell viability cellular stress response controlled study DNA damage gene induction genetic transcription genomic instability genotoxicity histone acetylation human human cell mouse nerve cell nonhuman oxidative stress protein expression protein protein interaction protein synthesis radiation injury ultraviolet radiation upregulation cell survival cytology drug effects genetics HEK293 cell line metabolism radiation response tumor cell line Cell Line, Tumor Cell Survival Cycloheximide Dactinomycin DNA Damage DNA Repair E2F1 Transcription Factor E2F2 Transcription Factor Genomic Instability HEK293 Cells Histones Humans Hydrogen Peroxide MAP Kinase Kinase Kinases Neurons p300-CBP Transcription Factors Protein Synthesis Inhibitors Rad51 Recombinase Ultraviolet Rays Up-Regulation
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_15384101_v14_n8_p1300_Castillo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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