Conformational states of 2′-C-methylpyrimidine nucleosides in single and double nucleic acid stranded structures

The hybridization performance of a set of 12-mer RNA:RNA duplexes containing 2′-C-methyluridine, 5-bromo-2′-C-methyluridine, or (2′S)-2′-deoxy-2′-C-methyluridine was analyzed. Melting point temperatures of the modified duplexes showed an important ΔTm decrease (-8.9 to -12.5 C), while circular dichr...

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Detalles Bibliográficos
Autores principales: Robaldo, L., Pontiggia, R., Di Lella, S., Estrin, D.A., Engels, J.W., Iribarren, A.M., Montserrat, J.M.
Formato: JOUR
Materias:
Computer simulation
Molecular dynamics
RNA
Conformational state
DNAzyme
Melting point temperature
Molecular dynamics simulations
Stem-loop structures
Structural knowledge
Biomolecules
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_15206106_v117_n1_p57_Robaldo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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