Calcium interactions with Cx26 hemmichannel: Spatial association between MD simulations biding sites and variant pathogenicity

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Connexinophaties are a collective of diseases related to connexin channels and hemichannels. In particular many Cx26 alterations are strongly associated to human deafness. Calcium plays an important role on this structures regulation. Here, using calcium as a probe, extensive atomistic Molecular Dyn...

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Detalles Bibliográficos
Autores principales: Albano, J.M.R., Mussini, N., Toriano, R., Facelli, J.C., Ferraro, M.B., Pickholz, M.
Formato: JOUR
Materias:
Connexin
Molecular dynamics
POPC
Variant annotation
Association reactions
Binding sites
Genes
Lipid bilayers
Amino acid interactions
Atomistic molecular dynamics simulations
Calcium concentration
Calcium distributions
Electron density profiles
Calcium
calcium
DFNA3 protein, human
gap junction protein
binding site
chemistry
genetics
hearing impairment
human
lipid bilayer
metabolism
molecular dynamics
mutation
Binding Sites
Connexins
Deafness
Humans
Lipid Bilayers
Molecular Dynamics Simulation
Mutation
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_14769271_v77_n_p331_Albano
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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