Microcrystalline cellulose as a carrier for hydrophobic photosensitizers in water
Samples of pheophorbide-a adsorbed on microcrystalline cellulose, which have been previously characterized in the solid state (M.G. Lagorio, E. San Roman, A. Zcug, J. Zimmermann and B. Röder, Phys. Chem. Chem. Phys., 2001, 3, 1524 1529), were washed with water, leading to stable suspensions of ultra...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_1474905X_v1_n3_p198_Zeug |
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todo:paper_1474905X_v1_n3_p198_Zeug2023-10-03T16:18:23Z Microcrystalline cellulose as a carrier for hydrophobic photosensitizers in water Zeug, A. Zimmermann, J. Röder, B. Lagorio, M.G. San Román, E. alcohol drug carrier hematoporphyrin microcrystalline cellulose monomer pheophorbide photosensitizing agent singlet oxygen water adsorption aqueous solution article chemical binding controlled study fluorescence hydrophobicity particle size priority journal solid state suspension Roman Samples of pheophorbide-a adsorbed on microcrystalline cellulose, which have been previously characterized in the solid state (M.G. Lagorio, E. San Roman, A. Zcug, J. Zimmermann and B. Röder, Phys. Chem. Chem. Phys., 2001, 3, 1524 1529), were washed with water, leading to stable suspensions of ultrafinc particles (d < 2 μm) carrying photoactive, monomeric dye molecules. Detachment can be controlled through the particle size distribution. Suspensions are fluorescent and generate singlet molecular oxygen efficiently. A similar effect has been observed on washing samples containing hematoporphyrin IX adsorbed on the same support. Thus, using cellulose as a heterogeneous carrier, it is possible to introduce hydrophobic photosensitizers into the aqueous medium while avoiding aggregation, thus preserving their photophysical properties. At the same time, the spectroscopic properties of dyes attached to cellulose particles are compared with those in ethanol and ethanol-water mixtures and their differences are explained in terms of medium polarity and dye aggregation. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_1474905X_v1_n3_p198_Zeug |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
alcohol drug carrier hematoporphyrin microcrystalline cellulose monomer pheophorbide photosensitizing agent singlet oxygen water adsorption aqueous solution article chemical binding controlled study fluorescence hydrophobicity particle size priority journal solid state suspension Roman |
| spellingShingle |
alcohol drug carrier hematoporphyrin microcrystalline cellulose monomer pheophorbide photosensitizing agent singlet oxygen water adsorption aqueous solution article chemical binding controlled study fluorescence hydrophobicity particle size priority journal solid state suspension Roman Zeug, A. Zimmermann, J. Röder, B. Lagorio, M.G. San Román, E. Microcrystalline cellulose as a carrier for hydrophobic photosensitizers in water |
| topic_facet |
alcohol drug carrier hematoporphyrin microcrystalline cellulose monomer pheophorbide photosensitizing agent singlet oxygen water adsorption aqueous solution article chemical binding controlled study fluorescence hydrophobicity particle size priority journal solid state suspension Roman |
| description |
Samples of pheophorbide-a adsorbed on microcrystalline cellulose, which have been previously characterized in the solid state (M.G. Lagorio, E. San Roman, A. Zcug, J. Zimmermann and B. Röder, Phys. Chem. Chem. Phys., 2001, 3, 1524 1529), were washed with water, leading to stable suspensions of ultrafinc particles (d < 2 μm) carrying photoactive, monomeric dye molecules. Detachment can be controlled through the particle size distribution. Suspensions are fluorescent and generate singlet molecular oxygen efficiently. A similar effect has been observed on washing samples containing hematoporphyrin IX adsorbed on the same support. Thus, using cellulose as a heterogeneous carrier, it is possible to introduce hydrophobic photosensitizers into the aqueous medium while avoiding aggregation, thus preserving their photophysical properties. At the same time, the spectroscopic properties of dyes attached to cellulose particles are compared with those in ethanol and ethanol-water mixtures and their differences are explained in terms of medium polarity and dye aggregation. |
| format |
JOUR |
| author |
Zeug, A. Zimmermann, J. Röder, B. Lagorio, M.G. San Román, E. |
| author_facet |
Zeug, A. Zimmermann, J. Röder, B. Lagorio, M.G. San Román, E. |
| author_sort |
Zeug, A. |
| title |
Microcrystalline cellulose as a carrier for hydrophobic photosensitizers in water |
| title_short |
Microcrystalline cellulose as a carrier for hydrophobic photosensitizers in water |
| title_full |
Microcrystalline cellulose as a carrier for hydrophobic photosensitizers in water |
| title_fullStr |
Microcrystalline cellulose as a carrier for hydrophobic photosensitizers in water |
| title_full_unstemmed |
Microcrystalline cellulose as a carrier for hydrophobic photosensitizers in water |
| title_sort |
microcrystalline cellulose as a carrier for hydrophobic photosensitizers in water |
| url |
http://hdl.handle.net/20.500.12110/paper_1474905X_v1_n3_p198_Zeug |
| work_keys_str_mv |
AT zeuga microcrystallinecelluloseasacarrierforhydrophobicphotosensitizersinwater AT zimmermannj microcrystallinecelluloseasacarrierforhydrophobicphotosensitizersinwater AT roderb microcrystallinecelluloseasacarrierforhydrophobicphotosensitizersinwater AT lagoriomg microcrystallinecelluloseasacarrierforhydrophobicphotosensitizersinwater AT sanromane microcrystallinecelluloseasacarrierforhydrophobicphotosensitizersinwater |
| _version_ |
1807321241908936704 |