Clinical relevance of ErbB-2/HER2 nuclear expression in breast cancer

Background: The biological relevance of nuclear ErbB-2/HER2 (NuclErbB-2) presence in breast tumors remains unexplored. In this study we assessed the clinical significance of ErbB-2 nuclear localization in primary invasive breast cancer. The reporting recommendations for tumor marker prognostic studi...

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Detalles Bibliográficos
Autores principales:	Schillaci, R., Guzmán, P., Cayrol, F., Beguelin, W., Díaz Flaqué, M.C., Proietti, C.J., Pineda, V., Palazzi, J., Frahm, I., Charreau, E.H., Maronna, E., Roa, J.C., Elizalde, P.V.
Formato:	JOUR
Materias:	epidermal growth factor receptor 2 steroid receptor tumor marker membrane protein nuclear protein accuracy adolescent adult article breast carcinoma cancer grading cancer invasion cancer prognosis cancer staging cancer survival cellular distribution clinical evaluation cohort analysis controlled study disease association female histopathology human human tissue immunofluorescence test immunohistochemistry major clinical study outcome assessment overall survival primary tumor process development protein expression protein function protein localization risk assessment sensitivity and specificity signal transduction tissue microarray tumor volume aged breast tumor carcinoma chemistry Chile Kaplan Meier method metabolism microarray analysis middle aged prognosis proportional hazards model Adult Aged Breast Neoplasms Carcinoma Cohort Studies Female Humans Immunohistochemistry Kaplan-Meier Estimate Membrane Proteins Microarray Analysis Middle Aged Nuclear Proteins Prognosis Proportional Hazards Models Receptor, erbB-2 Tumor Markers, Biological
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_14712407_v12_n_p_Schillaci
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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