Nucleoside phosphorylases

Nucleoside phosphorylases (NPs) are transferases that catalyse the reversible cleavage of the glycosidic bond of ribo- or deoxyribo nucleosides, in the presence of inorganic phosphate, to generate the base and ribose- or deoxyribose-1-phosphate. Since pyrimidine as well as purine nucleoside phosphor...

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Detalles Bibliográficos
Autores principales:	Lewkowicz, E.S., Iribarren, A.M.
Formato:	JOUR
Materias:	Azanucleosides Coupled enzymatic systems Glycosyltransfer reaction Immobilisation NP-I family TP-catalysed phosphorolysis 2 deoxyribose 2,6 diaminopurine 2',3' dideoxyriboside abacavir adenosine deaminase amdoxovir antiinfective agent antineoplastic agent azathioprine benzimidazole derivative cladribine cytarabine didanosine dihydropyrimidine dehydrogenase fludarabine gemcitabine glycoside lamivudine nicotinamide riboside nucleoside derivative nucleoside phosphorylase phosphate ribamidine ribavirin RNA directed DNA polymerase inhibitor stavudine tubercidin unindexed drug xanthine oxidase zalcitabine zidovudine antineoplastic activity antiviral activity binding affinity catalysis DNA synthesis drug screening drug structure drug synthesis drug targeting enzyme activity enzyme binding enzyme mechanism gene therapy glycosylation human nonhuman nucleotide metabolism review RNA synthesis structure activity relation structure analysis
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_13852728_v10_n11_p1197_Lewkowicz
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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