Deprotection of peracetylated methyl D-ribosides through enzymatic alcoholysis: Different recognition of the anomers

The anomers methyl 2,3,5-tri-O-acetyl-α-d-ribofuranoside and methyl 2,3,5-tri-O-acetyl-β-d-ribofuranoside showed a different behaviour in the Candida antarctica B lipase-catalysed alcoholysis. While the enzymatic deprotection of the former proceeded regioselectively affording methyl 2,3-di-O-acetyl-...

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Detalles Bibliográficos
Autores principales: Iñigo, S., Porro, M.T., Montserrat, J.M., Iglesias, L.E., Iribarren, A.M.
Formato: JOUR
Materias:
Deacetylation
Enzymatic alcoholysis
Lipases
Regioselectivity
Ribosides
Acetylation
Alcohols
Catalysis
Enzymes
Stereochemistry
Anomers
Isomers
furan derivative
lipase B
methyl 2,3 di o acetyl alpha dextro ribofuranoside
methyl 2,3,5 tri o acetyl beta dextro ribofuranoside
methyl 2.3.5 tri o acetyl alpha dextro ribofuranoside
methyl dextro riboside
unclassified drug
alcoholysis
article
biocatalyst
Candida antarctica
catalysis
deprotection reaction
diastereoisomer
enzyme mechanism
stereochemistry
temperature sensitivity
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_13811177_v35_n1-3_p70_Inigo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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