Glutathione-S-transferase (GST) polymorphisms are associated with relapse after radical prostatectomy

Background:Organ confined prostate cancer (PCa) can be cured by radical retropubic prostatectomy (RRP); however, some tumors will still recur. Current tools fail to identify patients at risk of recurrence. Glutathione-S- transferases (GSTs) are involved in the metabolism of carcinogens, hormones and...

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Detalles Bibliográficos
Autores principales: Cotignola, J., Leonardi, D.B., Shahabi, A., Acuña, A.D., Stern, M.C., Navone, N., Scorticati, C., De Siervi, A., Mazza, O., Vazquez, E.
Formato: JOUR
Materias:
biochemical relapse
glutathione-S-transferase
GST
polymorphism
glutathione transferase
glutathione transferase M1
glutathione transferase T1
prostate antigen
adult
age distribution
aged
Argentina
article
cancer growth
cancer recurrence
cancer staging
controlled study
DNA polymorphism
enzyme activity
family history
gene frequency
genetic variability
genotype
GSTM1 gene
GSTT1 gene
homozygosity
human
major clinical study
male
nucleotide sequence
oncogene
phenotype
priority journal
prostate cancer
prostatectomy
recurrence free survival
recurrence risk
retrospective study
risk assessment
risk factor
single nucleotide polymorphism
smoking
Aged
Case-Control Studies
Genetic Predisposition to Disease
Genotype
Glutathione Transferase
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasm Grading
Neoplasm Recurrence, Local
Neoplasm Staging
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Proportional Hazards Models
Prostatectomy
Prostatic Neoplasms
Risk Factors
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_13657852_v16_n1_p28_Cotignola
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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