Fertilization defects in sperm from Cysteine-rich secretory protein 2 (Crisp2) knockout mice: Implications for fertility disorders

Study hypothesis: We hypothesize that fertility disorders in patients with aberrant expression of Cysteine-RIch Secretory Protein 2 (CRISP2) could be linked to the proposed functional role of this protein in fertilization. study finding: Our in vivo and in vitro observations reveal that Crisp2-knock...

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Detalles Bibliográficos
Autores principales: Brukman, N.G., Miyata, H., Torres, P., Lombardo, D., Caramelo, J.J., Ikawa, M., Da Ros, V.G., Cuasnicú, P.S.
Formato: JOUR
Materias:
CRISP
Fertility
Fertilization
Hyperactivation
Knockout mice
Motility
Sperm
Testes
anazolene sodium
calcium
cysteine rich secretory protein 2
secretory protein
tyrosine
unclassified drug
CRISP2 protein, human
Crisp2 protein, mouse
glycoprotein
acrosome reaction
animal cell
animal experiment
Article
calcium cell level
controlled study
Crisp2 gene
cumulus oophorus
ejaculation
estrus
exon
female
fertilization
fertilization in vitro
flow cytometry
gene
gene deletion
in vitro study
in vivo study
knockout mouse
male
male fertility
male infertility
mating
mouse
nidation
nonhuman
phenotype
priority journal
protein expression
protein function
protein phosphorylation
semen analysis
spermatozoon capacitation
spermatozoon count
spermatozoon motility
superovulation
vasectomy
Western blotting
zona pellucida
adult
animal
deficiency
fertility
gene expression
genetics
human
Infertility, Male
litter size
metabolism
nucleotide sequence
pathology
pathophysiology
spermatozoon
Adult
Animals
Base Sequence
Calcium
Estrus
Exons
Female
Gene Expression
Glycoproteins
Humans
Litter Size
Male
Mice
Mice, Knockout
Sequence Deletion
Sperm Capacitation
Sperm-Ovum Interactions
Spermatozoa
Vasectomy
Zona Pellucida
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_13609947_v22_n4_p240_Brukman
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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