Trophoblast cells primed with vasoactive intestinal peptide enhance monocyte migration and apoptotic cell clearance through αvβ3 integrin portal formation in a model of maternal-placental interaction

study hypothesis: Is apoptotic cell phagocytosis by monocytes modulated by pathways elicited by vasoactive intestinal peptide (VIP) action on trophoblast? study finding: Targeting trophoblast cells with VIP induces monocyte migration, polarization to anti-inflammatory phenotypes and apoptotic tropho...

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Detalles Bibliográficos
Autores principales: Grasso, E., Calo, G., Vota, D., Hauk, V., Ramhorst, R., Leirós, C.P.
Formato: JOUR
Materias:
Apoptotic cell phagocytosis
Apoptotic trophoblast cells
Maternal-placental interface
Monocytes
Thrombospondin I
Vasoactive intestinal polypeptide
CD39 antigen
interleukin 10
thrombospondin 1
vasoactive intestinal polypeptide
vitronectin receptor
Article
cell clearance
cell differentiation
cell line
cell migration
cell phagocytosis
cellular parameters
coculture
controlled study
female
filters and membranes
first trimester pregnancy
flow cytometry
homeostasis
HTR8 cell line
human
human cell
in vitro study
macrophage activation
maternal placental interface
monocyte
normal human
parameters concerning the fetus, newborn and pregnancy
priority journal
protein expression
protein localization
reverse transcription polymerase chain reaction
Swan 71 cell line
trophoblast
upregulation
apoptosis
drug effects
metabolism
placenta
pregnancy
Apoptosis
Female
Humans
Integrin alphaVbeta3
Placenta
Pregnancy
Trophoblasts
Vasoactive Intestinal Peptide
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_13609947_v21_n12_p930_Grasso
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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