The dopamine D4 receptor is essential for hyperactivity and impaired behavioral inhibition in a mouse model of attention deficit/hyperactivity disorder

The dopamine D4 receptor (D4R) is a candidate gene for attention deficit/hyperactivity disorder (ADHD) based on genetic studies reporting that particular polymorphisms are present at a higher frequency in affected children. However, the direct participation of the D4R in the onset or progression of...

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Detalles Bibliográficos
Autores principales: Avale, M.E., Falzone, T.L., Gelman, D.M., Low, M.J., Grandy, D.K., Rubinstein, M.
Formato: JOUR
Materias:
6-hydroxydopamine
ADHD
Amphetamine
D4R knockout mouse
Methylphenidate
amphetamine
dopamine
dopamine 4 receptor
dopamine receptor blocking agent
methylphenidate
oxidopamine
sonepiprazole
animal experiment
animal model
article
attention deficit disorder
avoidance behavior
controlled study
dopaminergic system
female
genotype
male
maze test
mesencephalon
motor coordination
mouse
nonhuman
open field behavior
phenotype
priority journal
puberty
signal transduction
striate cortex
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_13594184_v9_n7_p718_Avale
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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