Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors

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Dopamine (DA) D2 receptors expressed in DA neurons (D 2 autoreceptors) exert a negative feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D2 receptors are mostly expressed in postsynaptic neurons, pharmacological and genetic approaches have been unable to definitivel...

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Detalles Bibliográficos
Autores principales: Bello, E.P., Mateo, Y., Gelman, D.M., Noaín, D., Shin, J.H., Low, M.J., Alvarez, V.A., Lovinger, D.M., Rubinstein, M.
Formato: JOUR
Materias:
cocaine
dopamine 2 receptor
dopamine autoreceptor
article
dopaminergic nerve cell
feeding behavior
motivation
motor performance
nerve cell inhibition
neurotransmission
priority journal
psychomotor activity
supersensitivity
synapse
Analysis of Variance
Animals
Autoradiography
Baclofen
Choice Behavior
Cocaine
Conditioning, Operant
Dihydroxyphenylalanine
Dopamine
Dopamine Agonists
Dopamine Antagonists
Dopamine Uptake Inhibitors
Drug Interactions
Enzyme Inhibitors
Exploratory Behavior
Food
GABA-B Receptor Agonists
Hydrazines
Hyperkinesis
Maze Learning
Membrane Potentials
Mesencephalon
Mice
Mice, Knockout
Motivation
Motor Activity
Neurons
Quinpirole
Receptors, Dopamine D2
Reinforcement Schedule
Reward
Sulpiride
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_10976256_v14_n8_p1033_Bello
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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