Characterization of the farnesyl pyrophosphate synthase of Trypanosoma cruzi by homology modeling and molecular dynamics

Chagas' disease, caused by the Trypanosoma cruzi parasite, is one of the largest public health problems in the Western hemisphere, with 16-18 million people infected, and approximately 100 million people at risk. Many efforts towards the development of targeted antiparasitic agents have recentl...

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Detalles Bibliográficos
Autores principales: Sigman, L., Sánchez, V.M., Turjanski, A.G.
Formato: JOUR
Materias:
Bisphosphonates
Chagas' disease
Farnesyl pyrophosphate synthase
Homology modeling
Molecular dynamics
Carbon
Diseases
Hydrogen bonds
Enzymes
bisphosphonic acid derivative
dimethylallylpyrophosphate
geranyltransferase
isopentyl pyrophosphate
magnesium ion
pyrophosphoric acid derivative
risedronic acid
threonine
transferase inhibitor
tyrosine
unclassified drug
article
Chagas disease
chemical binding
chemical model
chemical structure
enzyme active site
enzyme activity
enzyme analysis
enzyme substrate
human
hydrogen bond
molecular dynamics
molecular interaction
molecular model
nonhuman
nucleotide sequence
priority journal
sequence homology
Trypanosoma cruzi
Amino Acid Sequence
Animals
Binding Sites
Geranyltranstransferase
Models, Molecular
Molecular Sequence Data
Molecular Structure
Sequence Homology, Amino Acid
Structural Homology, Protein
Structure-Activity Relationship
Aves
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_10933263_v25_n3_p345_Sigman
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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