Optimization of a Bioluminescence Resonance Energy Transfer-Based Assay for Screening of Trypanosoma cruzi Protein/Protein Interaction Inhibitors

Chagas disease, a parasitic disease caused by Trypanosoma cruzi, is a major public health burden in poor rural populations of Central and South America and a serious emerging threat outside the endemic region, since the number of infections in non-endemic countries continues to rise. In order to dev...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Mild, J.G., Fernandez, L.R., Gayet, O., Iovanna, J., Dusetti, N., Edreira, M.M.
Formato: INPR
Materias:
BRET
Drug screening
Protein–protein interactions
Trypanosoma cruzi
Bioluminescence
Developing countries
Diagnosis
Energy transfer
Enzyme activity
Health risks
Phosphorescence
Bioluminescence resonance energy transfer
Functional characteristics
Protein interaction
Screening compounds
Suitable conditions
Drug interactions
antitrypanosomal agent
protein binding
protozoal protein
Central America
chemistry
drug effect
fluorescence resonance energy transfer
HEK293 cell line
human
metabolism
molecular library
pharmacology
preclinical study
procedures
protein analysis
South America
Drug Evaluation, Preclinical
Fluorescence Resonance Energy Transfer
HEK293 Cells
Humans
Protein Binding
Protein Interaction Maps
Protozoan Proteins
Small Molecule Libraries
Trypanocidal Agents
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_10736085_v_n_p1_Mild
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Ejemplares similares