Determining the virus life-cycle stage blocked by an antiviral

Among the members of the Arenaviridae family, Junín virus and Lassa virus represent important human health threats generating annual outbreaks of severe human hemorrhagic fever (HF) in endemic areas of Argentina and Western Africa, respectively. Given the lack of a specific and safe chemotherapy, th...

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Detalles Bibliográficos
Autores principales: Sepúlveda, C.S., García, C.C., Damonte, E.B.
Formato: SER
Materias:
Antiviral compound
Antiviral mechanism
Arenaviruses
antivirus agent
complementary DNA
Arenaviridae
cytopathogenic effect
cytotoxicity
cytotoxicity assay
disease severity
DNA synthesis
drug mechanism
EC50
endemic disease
hemorrhagic fever
high throughput screening
human
in vitro study
Junin virus
Lassa virus
life cycle stage
MTS assay
MTT assay
nonhuman
polyacrylamide gel electrophoresis
reverse transcription polymerase chain reaction
RNA synthesis
structure activity relation
virogenesis
virus assembly
virus attachment
virus culture
virus like agent
virus particle
virus release
virus replication
virus transcription
virus uncoating
Western blotting
drug effect
Hantaan virus
physiology
Antiviral Agents
Arenavirus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_10643745_v1604_n_p371_Sepulveda
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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