Electronic neuron within a ganglion of a leech (Hirudo medicinalis)

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We report the construction of an electronic device that models and replaces a neuron in a midbody ganglion of the leech Hirudo medicinalis. In order to test the behavior of our device, we used a well-characterized synaptic interaction between the mechanosensory, sensitive to pressure, (P) cell and t...

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Detalles Bibliográficos
Autores principales: Aliaga, J., Busca, N., Minces, V., Mindlin, G.B., Pando, B., Salles, A., Sczcupak, L.
Formato: JOUR
Materias:
agents interacting with transmitter, hormone or drug receptors
animal
biophysics
electrophysiology
ganglion
leech
metabolism
nerve cell
oscillometry
physiology
pressure
procedures
synapse
time
Animals
Biophysics
Electrophysiology
Ganglia
Leeches
Neurons
Neurotransmitter Agents
Oscillometry
Pressure
Synapses
Time Factors
Bifurcation (mathematics)
Cells
Electronic equipment
Graph theory
Mathematical models
Numerical analysis
Perturbation techniques
Andronov-Hopf bifurcation
Leech
Neuron
Saddle node bifurcation
Molecular biology
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_1063651X_v67_n6_p8_Aliaga
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:We report the construction of an electronic device that models and replaces a neuron in a midbody ganglion of the leech Hirudo medicinalis. In order to test the behavior of our device, we used a well-characterized synaptic interaction between the mechanosensory, sensitive to pressure, (P) cell and the anteropagoda (because of the action potential shape) (AP) neuron. We alternatively stimulated a P neuron and our device connected to the AP neuron, and studied the response of the latter. The number and timing of the AP spikes were the same when the electronic parameters were properly adjusted. Moreover, after changes in the depolarization of the AP cell, the responses under the stimulation of both the biological neuron and the electronic device vary in a similar manner. © 2003 The American Physical Society.

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