Dynamic coregulatory complex containing BRCA1, E2F1 and CtIP controls ATM transcription

Chromosomal instability is a key feature in cancer progression. Recently we have reported that BRCA1 regulates the transcription of several genes in prostate cancer, including ATM (ataxia telangiectasia mutated). Although it is well accepted that ATM is a pivotal mediator in genotoxic stress, it is...

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Detalles Bibliográficos
Autores principales: Moiola, C., De Luca, P., Cotignola, J., Gardner, K., Vazquez, E., De Siervi, A.
Formato: JOUR
Materias:
ATM
BRCA1
DNA damage
Prostate cancer
Transcription
2 morpholino 6 (1 thianthrenyl) 4 pyranone
ATM protein
BRCA1 associated ring domain protein 1
C terminal interacting protein
doxorubicin
etoposide
histone H2AX
methotrexate
mitoxantrone
protein
transcription factor E2F1
unclassified drug
article
binding site
cancer cell culture
chromatin
controlled study
genetic transcription
human
human cell
male
positive feedback
priority journal
promoter region
prostate cancer
protein binding
protein expression
protein phosphorylation
protein secretion
transcription regulation
Antibiotics, Antineoplastic
BRCA1 Protein
Carrier Proteins
Cell Cycle Proteins
Cell Line, Tumor
DNA Damage
DNA Repair
DNA-Binding Proteins
Doxorubicin
E2F1 Transcription Factor
Humans
Morpholines
Nuclear Proteins
Promoter Regions, Genetic
Protein Binding
Protein Structure, Tertiary
Protein-Serine-Threonine Kinases
Pyrones
Transcription, Genetic
Tumor Suppressor Proteins
Ataxia telangiectasia
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_10158987_v30_n3_p596_Moiola
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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