Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1β in the substantia nigra

The functional role of the long-lasting inflammation found in the substantia nigra (SN) of Parkinson's disease (PD) patients and animal models is unclear. Proinflammatory cytokines such as interleukin-1β (IL-1β) could be involved in mediating neuronal demise. However, it is unknown whether the...

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Detalles Bibliográficos
Autores principales: Ferrari, C.C., Pott Godoy, M.C., Tarelli, R., Chertoff, M., Depino, A.M., Pitossi, F.J.
Formato: JOUR
Materias:
Adenovector
Akinesia
Cytokine
Inflammation
Microglia
Parkinson
interleukin 1beta
Adenovirus
akinesia
animal experiment
animal model
animal tissue
article
astrocyte
cell activation
cell death
controlled study
disease course
dopaminergic nerve cell
immunohistochemistry
inflammatory infiltrate
male
microglia
motor dysfunction
nerve degeneration
nonhuman
pathogenesis
pathophysiology
priority journal
protein expression
rat
scar formation
substantia nigra
virus recombinant
Adenoviridae
Animals
Astrocytes
Cell Death
Cytokines
Dopamine
Genetic Vectors
Glial Fibrillary Acidic Protein
Interleukin-1
Macrophage Activation
Macrophages
Male
Motor Activity
Movement Disorders
Nerve Degeneration
Neuroglia
Neurons
Parkinson Disease, Secondary
Rats
Rats, Wistar
Substantia Nigra
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09699961_v24_n1_p183_Ferrari
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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