Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol

A series of 5-hydroxy-1,4-naphthoquinones analogues was synthesized from juglone (6) and their antiproliferative activity against a representative panel of six human solid tumor cell lines has been investigated. The 2,5-dihydroxy-3-(3-methylbut-2-enyl)naphthalene-1,4-dione (4) and 2,3-dihydro-5-hydr...

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Detalles Bibliográficos
Autores principales: Bonifazi, E.L., Ríos-Luci, C., León, L.G., Burton, G., Padrón, J.M., Misico, R.I.
Formato: JOUR
Materias:
Antiproliferative
Lapachol
Lapachone
Naphthoquinone
1,4 naphthoquinone derivative
2,3 dihydro 5 hydroxy 2 (prop 1 en 2 yl)naphtho[2,3 b]furan 4,9 dione
2,5 dihydroxy 3 (3 methylbut 2 enyl)naphthalene 1,4 dione
5 hydroxylapachol
juglone
lapachol
unclassified drug
article
cancer cell culture
drug activity
drug structure
drug synthesis
human
human cell
lipophilicity
prenylation
structure activity relation
Antineoplastic Agents, Phytogenic
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Indicators and Reagents
Lipids
Magnetic Resonance Spectroscopy
Naphthoquinones
Prenylation
Structure-Activity Relationship
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09680896_v18_n7_p2621_Bonifazi
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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