Antioxidant and cardioprotective effects of Ilex brasiliensis: A comparative study with Ilex paraguariensis (yerba mate)

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Our objective was to compare the antioxidant properties and cardiovascular effects in ischemia-reperfusion of leaves aqueous extracts of Ilex brasiliensis (B) and Ilex paraguariensis (P). In vitro systems were used to assess the antioxidant properties of the extracts. Isolated rat hearts were treate...

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Autores principales:	Schinella, G., Fantinelli, J.C., Tournier, H., Prieto, J.M., Spegazzini, E., Debenedetti, S., Mosca, S.M.
Formato:	JOUR
Materias:	Antioxidant capacity GSH Ilex brasiliensis Ilex paraguariensis Ischemia Reperfusion TBARS Ketones Organic acids Phenols Solvent extraction Croton ovalifolius Ilex Rattus
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_09639969_v42_n10_p1403_Schinella
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_09639969_v42_n10_p1403_Schinella
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spelling	todo:paper_09639969_v42_n10_p1403_Schinella2023-10-03T15:54:41Z Antioxidant and cardioprotective effects of Ilex brasiliensis: A comparative study with Ilex paraguariensis (yerba mate) Schinella, G. Fantinelli, J.C. Tournier, H. Prieto, J.M. Spegazzini, E. Debenedetti, S. Mosca, S.M. Antioxidant capacity GSH Ilex brasiliensis Ilex paraguariensis Ischemia Reperfusion TBARS Antioxidant capacity GSH Ilex brasiliensis Ilex paraguariensis Ischemia Reperfusion TBARS Ketones Organic acids Phenols Solvent extraction Croton ovalifolius Ilex Ilex brasiliensis Ilex paraguariensis Rattus Our objective was to compare the antioxidant properties and cardiovascular effects in ischemia-reperfusion of leaves aqueous extracts of Ilex brasiliensis (B) and Ilex paraguariensis (P). In vitro systems were used to assess the antioxidant properties of the extracts. Isolated rat hearts were treated with both extracts before ischemia and myocardial function was assessed. Thiobarbituric acid reactive substances (TBARS) concentration and reduced glutathione (GSH) were also measured. B extract showed higher total phenols and ascorbic acid contents and a higher scavenging activity of peroxynitrite and ferric reducing antioxidant power (FRAP) than P extract. Postischemic systolic and diastolic functions were improved after B and P treatment. Both extracts decreased TBARS and preserved GSH content. The present study demonstrates that an aqueous extract of I. brasiliensis, similar to I. paraguariensis, protects the myocardium against ischemia-reperfusion injury and attenuates oxidative damage. These effects may be attributed to the potent antioxidant properties of the extract. © 2009 Elsevier Ltd. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09639969_v42_n10_p1403_Schinella
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Antioxidant capacity GSH Ilex brasiliensis Ilex paraguariensis Ischemia Reperfusion TBARS Antioxidant capacity GSH Ilex brasiliensis Ilex paraguariensis Ischemia Reperfusion TBARS Ketones Organic acids Phenols Solvent extraction Croton ovalifolius Ilex Ilex brasiliensis Ilex paraguariensis Rattus
spellingShingle	Antioxidant capacity GSH Ilex brasiliensis Ilex paraguariensis Ischemia Reperfusion TBARS Antioxidant capacity GSH Ilex brasiliensis Ilex paraguariensis Ischemia Reperfusion TBARS Ketones Organic acids Phenols Solvent extraction Croton ovalifolius Ilex Ilex brasiliensis Ilex paraguariensis Rattus Schinella, G. Fantinelli, J.C. Tournier, H. Prieto, J.M. Spegazzini, E. Debenedetti, S. Mosca, S.M. Antioxidant and cardioprotective effects of Ilex brasiliensis: A comparative study with Ilex paraguariensis (yerba mate)
topic_facet	Antioxidant capacity GSH Ilex brasiliensis Ilex paraguariensis Ischemia Reperfusion TBARS Antioxidant capacity GSH Ilex brasiliensis Ilex paraguariensis Ischemia Reperfusion TBARS Ketones Organic acids Phenols Solvent extraction Croton ovalifolius Ilex Ilex brasiliensis Ilex paraguariensis Rattus
description	Our objective was to compare the antioxidant properties and cardiovascular effects in ischemia-reperfusion of leaves aqueous extracts of Ilex brasiliensis (B) and Ilex paraguariensis (P). In vitro systems were used to assess the antioxidant properties of the extracts. Isolated rat hearts were treated with both extracts before ischemia and myocardial function was assessed. Thiobarbituric acid reactive substances (TBARS) concentration and reduced glutathione (GSH) were also measured. B extract showed higher total phenols and ascorbic acid contents and a higher scavenging activity of peroxynitrite and ferric reducing antioxidant power (FRAP) than P extract. Postischemic systolic and diastolic functions were improved after B and P treatment. Both extracts decreased TBARS and preserved GSH content. The present study demonstrates that an aqueous extract of I. brasiliensis, similar to I. paraguariensis, protects the myocardium against ischemia-reperfusion injury and attenuates oxidative damage. These effects may be attributed to the potent antioxidant properties of the extract. © 2009 Elsevier Ltd. All rights reserved.
format	JOUR
author	Schinella, G. Fantinelli, J.C. Tournier, H. Prieto, J.M. Spegazzini, E. Debenedetti, S. Mosca, S.M.
author_facet	Schinella, G. Fantinelli, J.C. Tournier, H. Prieto, J.M. Spegazzini, E. Debenedetti, S. Mosca, S.M.
author_sort	Schinella, G.
title	Antioxidant and cardioprotective effects of Ilex brasiliensis: A comparative study with Ilex paraguariensis (yerba mate)
title_short	Antioxidant and cardioprotective effects of Ilex brasiliensis: A comparative study with Ilex paraguariensis (yerba mate)
title_full	Antioxidant and cardioprotective effects of Ilex brasiliensis: A comparative study with Ilex paraguariensis (yerba mate)
title_fullStr	Antioxidant and cardioprotective effects of Ilex brasiliensis: A comparative study with Ilex paraguariensis (yerba mate)
title_full_unstemmed	Antioxidant and cardioprotective effects of Ilex brasiliensis: A comparative study with Ilex paraguariensis (yerba mate)
title_sort	antioxidant and cardioprotective effects of ilex brasiliensis: a comparative study with ilex paraguariensis (yerba mate)
url	http://hdl.handle.net/20.500.12110/paper_09639969_v42_n10_p1403_Schinella
work_keys_str_mv	AT schinellag antioxidantandcardioprotectiveeffectsofilexbrasiliensisacomparativestudywithilexparaguariensisyerbamate AT fantinellijc antioxidantandcardioprotectiveeffectsofilexbrasiliensisacomparativestudywithilexparaguariensisyerbamate AT tournierh antioxidantandcardioprotectiveeffectsofilexbrasiliensisacomparativestudywithilexparaguariensisyerbamate AT prietojm antioxidantandcardioprotectiveeffectsofilexbrasiliensisacomparativestudywithilexparaguariensisyerbamate AT spegazzinie antioxidantandcardioprotectiveeffectsofilexbrasiliensisacomparativestudywithilexparaguariensisyerbamate AT debenedettis antioxidantandcardioprotectiveeffectsofilexbrasiliensisacomparativestudywithilexparaguariensisyerbamate AT moscasm antioxidantandcardioprotectiveeffectsofilexbrasiliensisacomparativestudywithilexparaguariensisyerbamate
_version_	1807323599170699264

Antioxidant and cardioprotective effects of Ilex brasiliensis: A comparative study with Ilex paraguariensis (yerba mate)

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