Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum

Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases such as cyclin-dependent kinases, glycogen synthase kinase-3, cyclic nucleo...

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Detalles Bibliográficos
Autores principales: Gompel, M., Leost, M., Bal De Kier Joffe, E., Puricelli, L., Hernandez Franco, L., Palermo, J., Meijer, L.
Formato: JOUR
Materias:
Cancer
CDK
Cyclin-dependent kinase
Glycogen synthase kinase
Glycogen synthase kinase-3
GSK-3
Kinase inhibitor
MEM
Meridianin
Modified Eagle Medium
MTT
Neurodegenerative diseases
Protein kinase
casein kinase I
cyclic nucleotide dependent protein kinase
cyclin dependent kinase
discodermindol
glycogen synthase kinase 3
isomeridianin c
isomeridianin g
meridianin
meridianin a
meridianin b
meridianin c
meridianin d
meridianin e
meridianin f
meridianin g
protein kinase inhibitor
psammopemmin a
psammopemmin b
psammopemmin c
unclassified drug
variolin b
Aplidium meridianum
apoptosis
article
Ascidiacea
cell death
cell division
cell proliferation
controlled study
drug mechanism
enzyme activity
enzyme inhibition
human
human cell
nonhuman
pharmacodynamics
Aminopyridines
Animals
Cell Division
Cell Line, Tumor
Cell Survival
Dose-Response Relationship, Drug
Enzyme Inhibitors
Humans
Indole Alkaloids
Mice
Protein Kinase Inhibitors
Urochordata
Aplidium
Ascidia
Ciconiiformes
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0960894X_v14_n7_p1703_Gompel
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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