Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome

The relationship between human chorionic gonadotropin and ovarian hyperstimulation syndrome (OHSS) is partially mediated by vascular endothelial growth factor A (VEGF). The aim of this study was to investigate the effects of VEGF inhibition on the development of corpora lutea (CL) and cystic structu...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Scotti, L., Abramovich, D., Pascuali, N., Irusta, G., Meresman, G., Tesone, M., Parborell, F.
Formato: JOUR
Materias:
Angiogenesis
Apoptosis
Cell proliferation
OHSS
Ovary
VEGF
aflibercept
angiogenesis inhibitor
claudin 5
Cldn5 protein, rat
estradiol
Flt1 protein, rat
hybrid protein
occludin
Ocln protein, rat
progesterone
vascular endothelial growth factor A, rat
vasculotropin A
vasculotropin receptor
vasculotropin receptor 1
vasculotropin receptor 2
unclassified drug
vascular endothelial growth factor receptor 1 fc chimera
vasculotropin
vasculotropin inhibitor
animal
antagonists and inhibitors
apoptosis
blood
cell proliferation
drug effects
endothelium cell
female
metabolism
ovary
ovary hyperstimulation
pathology
Sprague Dawley rat
animal experiment
animal model
animal tissue
Article
controlled study
corpus luteum
estradiol blood level
nonhuman
progesterone blood level
protein expression
protein phosphorylation
rat
steroidogenesis
Angiogenesis Inhibitors
Animals
Cell Proliferation
Claudin-5
Endothelial Cells
Estradiol
Female
Occludin
Ovarian Hyperstimulation Syndrome
Progesterone
Rats, Sprague-Dawley
Receptors, Vascular Endothelial Growth Factor
Recombinant Fusion Proteins
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factor Receptor-2
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09600760_v144_nPARTB_p392_Scotti
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The relationship between human chorionic gonadotropin and ovarian hyperstimulation syndrome (OHSS) is partially mediated by vascular endothelial growth factor A (VEGF). The aim of this study was to investigate the effects of VEGF inhibition on the development of corpora lutea (CL) and cystic structures, steroidogenesis, apoptosis, cell proliferation, endothelial cell area, VEGF receptors (KDR and Flt-1), claudin-5 and occludin levels in ovaries from an OHSS rat model. The VEGF inhibitor used (VEGF receptor-1 (FLT-1)/Fc chimera, TRAP) decreased the concentrations of progesterone and estradiol as well as the percentage of CL and cystic structures in OHSS rats, and increased apoptosis in CL. Endothelial cell area in CL and KDR expression and its phosphorylation were increased, whereas claudin-5 and occludin levels were decreased in the OHSS compared to the control TRAP reversed these parameters. Our findings indicate that VEGF inhibition prevents the early onset of OHSS and decreases its severity in rats. © 2014 Elsevier Ltd.

Ejemplares similares